Involvement of Centrosome Amplification in Radiation-Induced Mitotic Catastrophe
نویسندگان
چکیده
منابع مشابه
Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe.
Expression of the forkhead transcription factor FoxM1 correlates with proliferative status in a variety of normal and transformed cell types. Elevated expression of FoxM1 has been noted in both hepatocellular carcinoma and basal cell carcinoma. However, whether FoxM1 expression is essential for the viability of transformed cells is unknown. We report here that the expression of FoxM1 is signifi...
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Centrosome amplification is a hallmark of cancer, although we are still far from understanding how this process affects tumorigenesis [1, 2]. Besides the contribution of supernumerary centrosomes to mitotic defects, their biological effects in the post-mitotic cell are not well known. Here, we exploit the effects of centrosome amplification in post-mitotic cells during single-cell branching. We...
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Arsenite-induced mitotic abnormalities result in mitotic death in several cancer cell lines. However, how arsenite induces these effects is not known. We have previously shown that arsenite induces mitotic arrest, mitotic abnormalities, and mitotic death in CGL-2 cells. To further delineate the mechanism of action of arsenite, we examined its effect on centrosome duplication and the possible li...
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Tumor initiation and progression is dependent on the acquisition and accumulation of multiple driver mutations that activate and fuel oncogenic pathways and deactivate tumor suppressor networks. This complex continuum of non-stochastic genetic changes in accompaniment with error-prone mitoses largely explains why tumors are a mosaic of different cells. Contrary to the long-held notion that tumo...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.3.3834